Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs

Abstract Background Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers target drug and controlled system, however, the distribution of release are difficult to trace in cells. Therefore, construction a redox-sensitive multifunctional system intelligent anticancer drugs simultaneous diagnostic imaging therapy remains an attractive research subject. Results To construct smart chemotherapy, mPEG-ss-Tripp was prepared self-assembled into polymeric with diameter 105 nm that were easily detected within cells using confocal laser scanning microscopy based on aggregation-induced emission. Doxorubicin-loaded rapidly released intracellularly when GSH reduced disulfide bond. The drug-loaded inhibited tumor xenografts mice, while this efficacy lower without GSH-responsive bridge. These results establish innovative multi-functional micelle intracellular redox-triggered deliver Conclusions A novel AIE property constructed cellular release. This opens up new possibilities systems.